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American Journal of Innovative Research & Applied Sciences
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  | ARTICLES | Am. J. innov. res. appl. sci. Volume 4,  Issue 1, Pages 15-21 (January 2017)
 
American Journal of innovative
Research & Applied Sciences 
ISSN  2429-5396 (Online)
OCLC Number: 920041286
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| January | VOLUME 4 | N° 1 | 2017 |
Research Article
THE INFLUENCE OF SICKLE CELL ANEMIA ON LH, FSH, AMH, ESTRADIOL, VITAMIN D AND FERRITIN LEVELS OF SUDANESE FEMALES

 
| Mariam Abbas Ibrahim | Sara Abdalghani Siddiq Fgeer | Taysser Hassan Abdelaal Elhassan | Fadwa Eltayeb Mohamed Salih | Alaa Elbager Babiker  | Asgaed Yahya Ahmaed   | and |  Altaf Suleman Mosad Taaha  |. A
m. J. innov. res. appl. sci. 2017; 4(1):15-21.

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         |Received | 17 December 2016|         |Accepted | 27 December 2016|         |Published 31 December 2016 |
Authors Copyright © 2017| Mariam Abbas Ibrahim 1* | Sara Abdalghani Siddiq Fgeer 1 | Taysser Hassan Abdelaal Elhassan 1 | Fadwa Eltayeb Mohamed Salih 1 | Alaa Elbager Babiker 2 | Asgaed Yahya Ahmaed 2 | and | Altaf Suleman Mosad Taaha 1 | Fanantenansoa Asivelo Solonjara 2 | et | Frédéric Asimanana |
Authors Contact
This article is made freely available as part of this journal's Open Access. ID: | Mariam ManuscriptRef.1-ajiras171216 |
Authors Affiliation:
1. Sudan University of Science and Technology | College of Medical Laboratory Science | Clinical Chemistry Department | Khartoum | Sudan |

2. Sudan International University | College of Medical Laboratory Science | Department of chemical pathology | Khartoum | Sudan |
ABSTRACT

Background: As medical advances improve survival, reduce disease-related morbidity and improve quality of life; reproductive issues and fertility will take higher priority in sickle cell disease community, because every hundreds of thousands around world die from diseases caused by anemia. Objectives: This is a case control study was done to evaluate Estradiol, FSH, LH, serum Ferritin, AMH and Vitamin D levels among Sudanese females with sickle cell anemia, sickle cell trait and their correlations with duration of hydroxyurea treatment, blood transfusion and age. Methods: ELISA and Mindary MR-96A auto analyzer were used for evaluation. Results: Results were done by SPSS, showed that Sudanese females with sickle cell disease in comparison with females without sickle cell disease there were significantly increased in means concentration of serum (FSH, Ferritin) with P-value =(0.006, 0.000) respectively, significantly decreased in mean concentration of (Vitamin D)  with P-value = (0.020), and insignificant differences in means concentration of serum (AMH, LH and Estradiol) with P-value = (0.862, 0.947, 0.440) respectively. Also the subjects of diseased group were divided into two sub groups, sickle cell disease and sickle cell trait groups according to the electrophoresis bands, the results found that there were significant increase in means concentration of (FSH and Ferritin) with P-value = (0.044, 0.032) and (0.000, 0.005) respectively, and there were insignificant differences in means concentration of ( AMH, LH and Estradiol) with P-value = (0.997, 0.963), (0.916, 0.865) and (0.9, 0.8) respectively between sickle cell disease, sickle cell trait and control groups. In addition the results showed that there was insignificant difference in mean concentration of (Vitamin D) of females with sickle cell Trait in comparison with females without sickle cell disease P-value = (0.978). Conclusions: The concentration of serum FSH, Ferritin increased, concentration of Vitamin D decreased and there were insignificant difference between mean concentrations of AMH, LH & Estradiol among Sudanese females with sickle cell disease and sickle cell trait in comparison to healthy individuals. There was insignificant difference in mean concentration of Vitamin D of females with sickle cell Trait in comparison to control. There were negative correlation between the FSH and LH concentration and duration of hydroxyurea treatment, and there were no correlation between the Vitamin D, AMH, Ferritin and Estradiol concentration and duration of hydroxyurea treatment among Sudanese females patients. There were positive correlation between FSH and LH concentration and age, negative correlation between Vitamin D level and age and no correlation between AMH, Estradiol and Ferritin concentration and age among patients. There were no correlation between FSH, LH, Estradiol and Ferritin concentration and blood transfusion among Sudanese females with sickle cell anemia.
Keywords: Reproductive issue, Fertility, Hydroxyurea.