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| Info-AJIRAS-® Journal ISSN 2429-5396 (Online) / Reference CIF/15/0289M |
American Journal of Innovative Research & Applied Sciences
|
American Journal of innovative
Research & Applied Sciences
Research & Applied Sciences
ISSN 2429-5396 (Online)
OCLC Number: 920041286
OCLC Number: 920041286
Authors Contact
*Correspondant author and authors Copyright © 2024:
| Rakotonarivony Oberthe Carrel 1* | Rakotoarivony Mampionona Marino 2 | Manjovelo Sambany Christian 1 | Lahadson Stanislas Fulgence 2 | Razafimahatratra A.J. Hugues 1 | Wadouachi Anne 3 | Josse Solen 3 | et | Rasoanaivo Herilala Léa 2|
Affiliation.
1. University of Toliara | Faculty of Sciences | Toliara Ecole Doctorale | Géosciences, Physique, Chimie de l’Environnement et Système Hôte Pathogène | | Madagascar |
2. University of Antananarivo | Faculty of Sciences | Laboratoire de Chimie des Substances Naturelles et Chimie Organique Biologique | Antananarivo | Madagascar |
3. University of Picardie Jules Verne | Institut de Chimie de Picardie | Laboratoire de Glycochimie et des Agroressources d’Amiens UR 7378 | Amiens | France |
This article is made freely available as part of this journal's Open Access:
| DOI: https://doi.org/10.5281/zenodo.12705906|
*Correspondant author and authors Copyright © 2024:
| Rakotonarivony Oberthe Carrel 1* | Rakotoarivony Mampionona Marino 2 | Manjovelo Sambany Christian 1 | Lahadson Stanislas Fulgence 2 | Razafimahatratra A.J. Hugues 1 | Wadouachi Anne 3 | Josse Solen 3 | et | Rasoanaivo Herilala Léa 2|
Affiliation.
1. University of Toliara | Faculty of Sciences | Toliara Ecole Doctorale | Géosciences, Physique, Chimie de l’Environnement et Système Hôte Pathogène | | Madagascar |
2. University of Antananarivo | Faculty of Sciences | Laboratoire de Chimie des Substances Naturelles et Chimie Organique Biologique | Antananarivo | Madagascar |
3. University of Picardie Jules Verne | Institut de Chimie de Picardie | Laboratoire de Glycochimie et des Agroressources d’Amiens UR 7378 | Amiens | France |
This article is made freely available as part of this journal's Open Access:
| DOI: https://doi.org/10.5281/zenodo.12705906|
| ISSN: 2429-5396 (e) | https://www.american-jiras.com | |
| Web Site Form: v 0.1.05 | JF 22 Cours, Wellington le Clairval, Lillebonne | France |
| Web Site Form: v 0.1.05 | JF 22 Cours, Wellington le Clairval, Lillebonne | France |
Abstarct7-December-2023
| JULY 19 | ISSUE N° 1 | 2024 |
| ARTICLES | Am. J. innov. res. appl. sci. Volume 19, Issue - 1 Pages 1-7 (July, 2024)
| ARTICLES | Am. J. innov. res. appl. sci. Volume 19, Issue - 1 Pages 1-7 (July, 2024)
ABSTRACT
Background: Nuxia capitata Baker (Stilbaceae) is traditionally used as an anti-fatigue remedy, but its efficacy is not well-documented. Objectives : This study aimed to validate the traditional use of this plant. Methods : Hexane (7.42%), ethyl acetate (2.01%), and methanol extracts (5.12%) were obtained by maceration. Antioxidant activity was evaluated using biotographie with DPPH. The forced swimming endurance test and modified string test were performed to assess anti-fatigue activities. Compounds from the active extract were isolated by liquid chromatography. Results: All extracts demonstrated potent antioxidant activity. Treatment with hexane or ethyl acetate extracts improved performance in the modified string test, with the ethyl acetate extract at 100 mg/kg showing the highest effect. Swimming times were significantly longer in all treated mice except those treated with hexane extract or high doses of extracts (200 mg/kg). Fractionation of the ethyl acetate extract led to the isolation of six known compounds, including three triterpenoids (ursolic acid, oleanolic acid, and taraxasterol acid) and three flavones (cirsimaritin, negletein, and quercetin). Conclusion : This study significantly enhances the understanding of the chemistry and pharmacology of N. capitata, suggesting that the plant is a promising treatment for combating fatigue and oxidation-related diseases.
Keywords : Nuxia capitata, phytochemical, Antioxidant, anti-fatigue.
Background: Nuxia capitata Baker (Stilbaceae) is traditionally used as an anti-fatigue remedy, but its efficacy is not well-documented. Objectives : This study aimed to validate the traditional use of this plant. Methods : Hexane (7.42%), ethyl acetate (2.01%), and methanol extracts (5.12%) were obtained by maceration. Antioxidant activity was evaluated using biotographie with DPPH. The forced swimming endurance test and modified string test were performed to assess anti-fatigue activities. Compounds from the active extract were isolated by liquid chromatography. Results: All extracts demonstrated potent antioxidant activity. Treatment with hexane or ethyl acetate extracts improved performance in the modified string test, with the ethyl acetate extract at 100 mg/kg showing the highest effect. Swimming times were significantly longer in all treated mice except those treated with hexane extract or high doses of extracts (200 mg/kg). Fractionation of the ethyl acetate extract led to the isolation of six known compounds, including three triterpenoids (ursolic acid, oleanolic acid, and taraxasterol acid) and three flavones (cirsimaritin, negletein, and quercetin). Conclusion : This study significantly enhances the understanding of the chemistry and pharmacology of N. capitata, suggesting that the plant is a promising treatment for combating fatigue and oxidation-related diseases.
Keywords : Nuxia capitata, phytochemical, Antioxidant, anti-fatigue.
| Rakotonarivony Oberthe Carrel 1* | Rakotoarivony Mampionona Marino 2 | Manjovelo Sambany Christian 1 | Lahadson
Stanislas Fulgence 2 | Razafimahatratra A.J. Hugues 1 | Wadouachi Anne 3 | Josse Solen 3 | and | Rasoanaivo Herilala Léa 2|.
Am. J. innov. res. appl. sci. 2024; 19(1):1-7.