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  | ARTICLE  | Am. J. innov. res. appl. sci. Volume 15,  Issue-1, Pages 371-375 (July, 2022)
   Research Article 10
 
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  American Journal of Innovative Research & Applied Sciences
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American Journal of innovative
Research & Applied Sciences 
ISSN  2429-5396 (Online)
OCLC Number: 920041286
Authors Contact

*Correspondant author and authors Copyright © 2022:

| Tohandrainy, Mbola Adrien 1 | Rakotoarison, Olivier 2* | Lahadson, Stanislas Fulgence 3 | Rabemandroso, Faramalala Louise 3 | Ravelomanantsoa, Germier 4 | and | Rajemiarimiraho, Manitriniaina 3,5 |

Affiliation.


1. Ecole Régionale de Santé Publique (ERSP) | Sud-Kivu-RDC |
2Institut Supérieur d’Agroforesterie et de Gestion de l’Environnement de Kahuzi Biega | Sud-Kivu-RDC |
3. Institut Supérieur des Techniques Médicales de Bukavu | Sud-Kivu-RDC |
4. Université Officielle de Bukavu | Sud-Kivu-RDC |


This article is made freely available as part of this journal's Open Access: ID | Ohandrainy-Ref14-ajira300622 | 
| JULY | VOLUME 15 | ISSUE N° 1 | 2022 |
ABSTRACT

Background: Cassia occidentalis (Caesalpiniaceae) is used in traditional medicine to treat many diseases including hypertension. Objectives: This study evaluated the potential hypotensive and antihypertensive effects of aqueous extract of its roots. Methods: Roots extract (EABCO) was made by decoction. The activity of EABCO was tested in vivo on normotensive rabbits under anesthesia for arterial pressure lowering effect. The responses were measured using Ludwig manometer. Results: With dose going from 100 to 500 mg/kg of body weight (b.w.) EABCO, there is an induction of hypotension comparable to that seen with acetylcholine at the doses from 1 to 20ɣ/kg. The study of Adrenalin-EABCO antagonism has shown an inhibit hypertensive property of EABCO at a dose of 25, 50 or 100 mg/kg of body weight. EABCO act as a noncompetitive inhibitor of adrenoceptor, justified by a parallel shift to the right from the cumulative dose-response curve and no attained bend. Conclusions: Results indicate that aqueous extract of roots of Cassia occidentalis possess hypotensive and antihypertensive properties. Cholinomimetic and/or noncompetitive adrenoceptor blocking actions may explain in part the antihypertensive potential of this plant and provides a potential pharmacological base to its medicinal use in the management of hypertension.
Keywords: Cassia occidentalis, hypotension, antihypertension.
HYPOTENSIVE AND ANTIHYPERTENSIVE PROPERTIES OF AQUEOUS EXTRACT OF Cassia occidentalis (Caesalpiniaceae) ROOTS ON ANESTHETIZED RABBITS


| Tohandrainy, Mbola Adrien 1 | Rakotoarison, Olivier 2* | Lahadson, Stanislas Fulgence 3 | Rabemandroso, Faramalala Louise 3 | Ravelomanantsoa, Germier 4 | and | Rajemiarimiraho, Manitriniaina 3,5 |.  Am. J. innov. res. appl. sci.  2022; 15(1):341-371-375.

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