American Journal of Innovative Research & Applied Sciences
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  | ARTICLES | Am. J. innov. res. appl. sci. Volume 3,  Issue 3, Pages 508-511 (December 2016)
| December | VOLUME 3 | N° 3 | 2016 |
Research Article
 
HISTOLOGIC ALTERATIONS IN THE KIDNEY OF CLARIAS GARIEPINUS EXPOSED TO ETHANOLIC EXTRACT OF DENNETTIA TRIPETALA

   | Isangedighi Asuquo Isangedighi | and | Eyo, Etim Ambrose  |. Am. J. innov. res. appl. sci. 2016; 3(3):508-511.
  
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|Received | 26 October 2016|          |Accepted | 13 November 2016|         |Published 20 November 2016 |

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Authors Copyright © 2016:

| Isangedighi, Asuquo Isangedighi 1 | and | Eyo, Etim Ambrose 1 |


Authors Affiliation:


1. University of Uyo | Department of Fisheries and Aquatic Environmental Management | Uyo | Nigeria | 
This article is made freely available as part of this journal's Open Access. ID: | Isangedighi ManuscriptRef.1-ajiras261016 |
ABSTRACT

Background: The description and assessment of histological changes in different organs represent a very sensitive and crucial parameters in determining the impact of toxicants on the ecosystem. To understand the impact of toxicants in aquatic ecosystems, it is necessary to study the histopathological effects of poisons on different fish organs. Patent on kidney toxicity relates the term ‘kidney toxicity’ to any damage or impairment of the kidney which results in an impaired kidney function, in particular, impaired tubular or glomerular function. Objective:  This research was aimed at assessing the ichthyotoxic potential of Dennettia tripetala fruit extract by investigating its effects on the histology of the kidney of Clarias gariepinus (Catfish). Methods: Fingerlings of Clarias gariepinus (size and body weight ranged from 3.9 – 7.6cm and 0.08 – 3.75g respectively) were exposed to sublethal dose of 0.7g/l (96hrs LC50) and a lethal dose of 1.2g/l of ethanolic extract of D. tripetala using static bioassay. Results: Kidney tissue treated with sublethal dose (0.7g/l ) of D. tripetala revealed condensed renal corpuscle filled with glomerular inflammation while kidney tissue treated with 1.2g/l of the toxicant revealed tubular necrosis and cellular degeneration. These findings revealed the deleterious potency of D. tripetala on fish kidney. No fish survived the lethal concentration of 1.2g/l of the toxicant. Conclusions: The lesions in the kidney tissue of the fish are attributable to the ichthyotoxic nature of the botanical. Lethal concentrations of Dennettia tripetala fruit extract could serve as an environmentally friendly alternative to synthetic piscicides used in fish pond to eliminate unwanted fish prior to stocking with desirable fish species.

Keywords: Ichthyotoxic, Pesticide, Dennettia tripetala, Clarias gariepinus, lesion, kidney.
American Journal of innovative
Research & Applied Sciences 
ISSN  2429-5396 (Online)
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