| ABSTRACT | Volume 1, Issue 1, Pages 10-13 (March 2015)

Research Article    ASSAY OF FEXOFENADINE BRANDS USING UV SPECTROPHOTOMETER.     | Naveed S  | Qamar F  | Zainab S  | Sarwar G  |  and  | Tanweer A.M  |. American Journal of Innovative Research and Applied Sciences. 2015; 1(1): 10-13.    | PDF  FULL TEXT |

ABSTRACT Background: Fexofenadine is widely used drug for Rhinitis. It is a selective histamine H1 receptor antagonist. Objectives: In our recent research we developed a least time consuming simple and efficient UV spectrophotometric method for the assay of fexofenadine. Methods: The assay is based on the Ultraviolet Spectroscopy (UV) measuring absorbance maxima at about 220nm wavelength of fexofenadine. A sample of drug was dissolved in water to produce a solution containing furosemide. Similarly, a sample of ground tablets of two different brands of fexofenadine were dissolved in water and various dilutions were made. Results: The absorbance of sample preparation was measured at 220nm against the solvent blank. Regression line was obtained for different dilutions. Conclusion: The analysis shows a linear relationship between absorbance and concentration. Thus the use of UV spectrometry is easy technique to assess fexofenadine concentration. KEY WORDS: Fexofenadine, spectroscopy, Telefast, Xanidine, UV spectrophotometer.