| ABSTRACT | Volume 1, Issue 1, Pages 10-13 (March 2015)
| Naveed S | Qamar F | Zainab S | Sarwar G | and | Tanweer A.M |. American Journal of Innovative Research and Applied Sciences. 2015; 1(1): 10-13.
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Background: Fexofenadine is widely used drug for Rhinitis. It is a selective histamine H1 receptor antagonist. Objectives: In our recent research we developed a least time consuming simple and
efficient UV spectrophotometric method for the assay of fexofenadine. Methods: The assay is based on the Ultraviolet Spectroscopy (UV) measuring absorbance maxima at about 220nm
wavelength of fexofenadine. A sample of drug was dissolved in water to produce a solution containing furosemide. Similarly, a sample of ground tablets of two different brands of fexofenadine were
dissolved in water and various dilutions were made. Results: The absorbance of sample preparation was measured at 220nm against the solvent blank. Regression line was obtained for different
dilutions. Conclusion: The analysis shows a linear relationship between absorbance and concentration. Thus the use of UV spectrometry is easy technique to assess fexofenadine concentration.
KEY WORDS: Fexofenadine, spectroscopy, Telefast, Xanidine, UV spectrophotometer.