American Journal of Innovative Research & Applied Sciences
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Authors Copyright © 2015: | Labaran Ibrahim |
| | ABSTRACT |Volume 1, Issue 4, Pages 128-132 (June 2015) |
| Research article EFFECT OF ORAL ADMINISTRATION OF ALBEZIA LEBBECK AQUEOUS STEM BARK EXTRACT ON SOME LIVER FUNCTION INDICES IN RATS | Labaran Ibrahim |. American Journal of Innovative Research and Applied Sciences. 2015; 1(4)128-132. |PDF FULL TEXT| |
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Instituation affiliation:
Federal University | Dutse | Department of Biochemistry | College of Medicine and Allied Health Professions | Dutse | Nigeria |
Federal University | Dutse | Department of Biochemistry | College of Medicine and Allied Health Professions | Dutse | Nigeria |
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American Journal of innovative
Research & Applied Sciences
Research & Applied Sciences
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ABSTRACT
Background: Albizia Lebbeck is also used in traditional system and folk medicine as well as to treat several inflammatory conditions such as asthma, arthritis, allergic rhinitis, bronchitis, helminthes infections and burns. Objective: this study is undertaken to ascertain the effect of oral administration of Albizia Lebbeck aqueous stem bark extract on some liver function indices in albino rats. Materials and Methods: The effect of Albizia lebbeck aqueous stem bark extract administered orally for twenty four days (24) was studied in albino rats. The research work was undertaken to ascertain serum concentrations or activities of some liver enzymes; Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) and Alkaline phosphatase (ALP) and also the levels of Total bilirubin (TBIL). During this study, sixteen (16) albino rats were used and divided into four (4) groups. Group I served as control. However, Groups II, III and IV were considered to be test groups and were administered with Albizia Lebbeck aqueous stem bark extract of 100, 300 and 500mg/kg body weight dosage respectively. The mean serum activities of enzymes AST, ALT, were determined using the method of Reitman ad Frankel, 1957, ALP According to the Method of Klein, Read and Babson (1960) however, that of TBIL levels by the method of Jendrassik and Grof, 1938. Mean serum levels of AST, ALT, ALP and TBIL for each dose of 100, 300 and 500mg/kg body weight were found to be; [22.18±03.10U/L, 25.00±04.22U/L, 150.85±30.99U/L and 11.97±02.42mm/L], [27.38±02.74U/L, 35.70±05.02U/L, 175.35±34.83U/L and 13.26±04.50mm/L] and [45.40±07.18U/L, 55.45±09.69U/L, 218.83±56.35U/L and 15.39±10.34mm/L] respectively. However, control results for the above parameters (AST, ALT, ALP and TBIL) of; [15.01±02.15U/L, 13.90±01.76U/L, 57.53±08.67U/L and 11.97±05.76mm/L] were also obtained respectively. Therefore, the results of this work indicated a significant increases (p<0.05) in the AST, ALT and ALP activities of test groups in comparison with control. Hence, the level of TBIL in the test groups revealed no significant increases (p>0.05) in comparison with control. Conclusion: We revealed that daily oral administration of aqueous stem bark extract of Albizia lebbeck for 24 days induced significantly hepato-toxicity in rats at the administered doses with elevated levels of AST, ALT, ALP and TBIL concentrations.
Keywords: Aspartate aminotransferase, Alanine aminotransferase, Akaline phosphatase, Total bilirubin, Serum, control
Background: Albizia Lebbeck is also used in traditional system and folk medicine as well as to treat several inflammatory conditions such as asthma, arthritis, allergic rhinitis, bronchitis, helminthes infections and burns. Objective: this study is undertaken to ascertain the effect of oral administration of Albizia Lebbeck aqueous stem bark extract on some liver function indices in albino rats. Materials and Methods: The effect of Albizia lebbeck aqueous stem bark extract administered orally for twenty four days (24) was studied in albino rats. The research work was undertaken to ascertain serum concentrations or activities of some liver enzymes; Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) and Alkaline phosphatase (ALP) and also the levels of Total bilirubin (TBIL). During this study, sixteen (16) albino rats were used and divided into four (4) groups. Group I served as control. However, Groups II, III and IV were considered to be test groups and were administered with Albizia Lebbeck aqueous stem bark extract of 100, 300 and 500mg/kg body weight dosage respectively. The mean serum activities of enzymes AST, ALT, were determined using the method of Reitman ad Frankel, 1957, ALP According to the Method of Klein, Read and Babson (1960) however, that of TBIL levels by the method of Jendrassik and Grof, 1938. Mean serum levels of AST, ALT, ALP and TBIL for each dose of 100, 300 and 500mg/kg body weight were found to be; [22.18±03.10U/L, 25.00±04.22U/L, 150.85±30.99U/L and 11.97±02.42mm/L], [27.38±02.74U/L, 35.70±05.02U/L, 175.35±34.83U/L and 13.26±04.50mm/L] and [45.40±07.18U/L, 55.45±09.69U/L, 218.83±56.35U/L and 15.39±10.34mm/L] respectively. However, control results for the above parameters (AST, ALT, ALP and TBIL) of; [15.01±02.15U/L, 13.90±01.76U/L, 57.53±08.67U/L and 11.97±05.76mm/L] were also obtained respectively. Therefore, the results of this work indicated a significant increases (p<0.05) in the AST, ALT and ALP activities of test groups in comparison with control. Hence, the level of TBIL in the test groups revealed no significant increases (p>0.05) in comparison with control. Conclusion: We revealed that daily oral administration of aqueous stem bark extract of Albizia lebbeck for 24 days induced significantly hepato-toxicity in rats at the administered doses with elevated levels of AST, ALT, ALP and TBIL concentrations.
Keywords: Aspartate aminotransferase, Alanine aminotransferase, Akaline phosphatase, Total bilirubin, Serum, control